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2017 President's Lecture
preceeded by AGM


Annual General Meeting
Wednesday, 29 November 2017 at 5.00pm

Linnean Society
Burlington House
London, UK

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On the Malleability of Genomes

Dr Mary O'Connell
University Academic Fellow in Biology

University of Leeds

6.00pm Wednesday 29 November 2017
at the Linnean Society, London

The relationship between sequence and function has proven difficult to fully elucidate but it is key to understanding what makes a species unique. Large-scale studies can help to bridge the gap in our understanding by revealing major patterns in the data that correlate genotype with function or phenotype. We take two complementary approaches to identifying the evolution of species-specific proteins/protein functions using genome-scale data and computational evolutionary models. I will present some work we have undertaken, using a phylogenetic approach, on the link between genotype, phenotype, fitness and indeed behaviour. In particular I will describe how taking an applied evolutionary approach to modelling the mammal innate immune system may provide us with an increased understanding of species-specific response to disease/drugs at the molecular level. To finish, I will present some snapshots from our ongoing work into the identification of "new genes' - some of which are species-specific.”.

Wine will be served after the lecture to members and their guests

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